This book constitutes the thoroughly refereed postproceedings of the International Conference on Computational Methods in Systems Biology, CMSB 2004, held in Paris, France in May 2004.

The 16 revised full papers and 7 revised short papers presented together with an invited paper went through two rounds of reviewing, selection and revision. The papers present a variety of techniques from computer science, such as language design, concurrency theory, software engineering, and formal methods, for biologists, physicists, and mathematicians interested in the systems-level understanding of cellular processes.