Seven articles edited by one of the pioneers of microcolumn liquid chromatography present the background necessary for understanding what microscale HPLC is and how it can be utilized. The chapters cover instrumental requirements, microcolumn techniques, new detection systems, derivatization, and applications. The articles also provide hints about the direction of current research along with a directory of applications. This book is written as a textbook, but is also suitable for professionals who are new to microscale liquid chromatography or who are taking a short course in it.