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Название: Exploiting the Diversity of Time Scales in the Immune System: A B-Cell Antibody Model
Авторы: Segel L.A., Perelson A.S.
Journal of Statistical Physics, Vol. 63, Nos. 5/6, 1991. p. 1113-1131.
Using the continuous shape space formalism, we develop an immune system model involving both B lymphocytes and antibody molecules. The binding and cross-linking of receptors on B cells stimulates the cells to divide and, with a lag, to secrete antibody. Using the method of multiple scales, we show how to correctly formulate long-time-scale equations for the population dynamics of B cells, the total antibody concentration, and rate of antibody secretion. We compare our model with previous phenomenological formulations.