Journal of Statistical Physics, Vol. 52, Nos. 1/2, 1988. p. 519-520.
The idea that the role of the protein in enzymatic catalysis is not merely geometrical but also dynamical is central in the modern study of biophysical kinetics. According to this point of view, the protein is not just
a static structure, forming the "keyhole" that complements the shape of its substrate: It also participates actively in the reactive event through the dynamics of conformational change...