Journal of Statistical Physics, Vol. 90, Nos. 1/2, 1998. p. 191-210.
The role of mutational bias in evolution on a smooih landscape is invesligatcd. We consider both a finite-length genome where the bias increases linearly with the fitness, and an infinite genome with a fixed bias. We present simulations of finite populations in a wailing time model, showing both the nonequilibrium dynamics and the equilibrium fitness distributions that are reached, We compute the equilibrium analytically in several cases, using approximate direct solution of the master equations and truncated hierarchies.