CLinicaL Prediction RuLes: A PhysicaL Therapy Reference ManuaL by Drs. Paul Glynn and P. Cody Weisbach will make a substantial and timely contribution to the physical therapy profession. The profession recently experienced an influx in the development of clinical prediction rules (CPRs), which provide physical therapists with an evidence-based tool to assist in patient management when determining a particular diagnosis or ptognosis, or when predicting a response to a particular intervention. Clinicians often are left without evidence to guide clinical decision making. CPRs make terrific contributions to the evidence available to physical therapists and will greatly enhance the quality of care provided to patients. Drs. Glynn and Weisbach have taken the first step in the much-needed process of ensuring that CPRs are used on a consistent basis. They have provided a user-friendly guide to understanding the principles and utilization of CPRs in physical therapy practice. Furthermore, ClinicaL Prediction RuLes: A PhysicaL Therapy Reference ManuaL provides an extensive list of CPRs that have been developed and the potential implications for the patients whom physical therapists treat.