Orthodox Copenhagen quantum theory renounces the quest to understand the reality in which we are imbedded, and settles for practical rules that describe connections between our observations. Many physicist have believed that this renunciation of the attempt describe nature herself was premature, and John von Neumann, in a major work, reformulated quantum theory as a theory of the evolving objective universe. In the course of his work he converted to a benefit what had appeared to be a severe deficiency of the Copenhagen interpretation, namely its introduction into physical theory of the human observers. He used this subjective element of quantum theory to achieve a significant advance on the main problem in philosophy, which is to understand the relationship between mind and matter. That problem had been tied closely to physical theory by the works of Newton and Descartes. The present work examines the major problems that have appeared to block the development of von Neumann's theory into a fully satisfactory theory of Nature, and proposes solutions to these problems.