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Helmreich E.J.M. — Biochemistry of Cell Signalling
Helmreich E.J.M. — Biochemistry of Cell Signalling



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Íàçâàíèå: Biochemistry of Cell Signalling

Àâòîð: Helmreich E.J.M.

Àííîòàöèÿ:

The Biochemistry of Cell Signalling deals in depth with the principles of cell signalling, concentrating on structure and mechanism. It will serve as a reliable map through the maze of cell signalling pathways and help the reader understand how malfunctions in these pathways can lead to disease. The book is divided into four parts. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor activation), regulators, and the molecules that link receptor and regulator. The design of signalling cascades is explained by describing central signalling pathways: the Ras-regulated MAPK and PI-3 pathways; the Rho/Rac/Cdc 42 pathway controlling chemotaxis and regulating the cytoskeleton; the G protein coupled receptor cascades in response to sensory and hormonal signals; signalling by TGF-ss in morphogenesis; cytokine signalling that controls haemopoiesis. There is also a discussion of the insulin response. As phosphorylation - dephosphorylation is involved in nearly all cellular regulatory processes, Part 1 concludes with a synopsis of its role in signalling. Part 2 describes the implementation of the signalling cascades focusing on the effect on gene transcription. After a brief description of the transcriptional machinery the regulation of transcription by cytokines and growth factors in the control of cell growth and the mechanisms and sites of control are discussed in detail. The regulators discussed include Jun/Fos, NF-AT, SREBPs, and STATs. The next two chapters cover gene regulation by nuclear receptors, including both the steroid hormone receptors and non-steroid nuclear receptors e.g. the retinoic acid receptors RAR and RXR. Part 3 studies the global cellular regulatory programs for the control of cell growth and proliferation. The first chapter concerns the regulation of the cell cycle and the role of the cyclin-dependent kinases, telomerase, Ran, and cell cycle checkpoints. The next topic is the signalling pathways in apoptosis: the TNF-receptor family death receptors, caspases, and the intracellular apoptosis signals and the role of apoptosis in the lifecycle of cells. Part 3 ends with a discussion of the signal pathways involved in the immune response, focusing on the involvement of cell-cell interactions. Part 4 considers loss of regulatory control and its consequences with respect to the molecular basis of cancer. It first describes the cellular regulatory proteins that have oncogenic potential, how they can become oncogenic and cause the transformation of normal cells to cancerous cells. Next is an analysis of the loss of developmental controls, the APC protein, ss-catenin, and the Wnt pathway, that lead to mature terminally differentiated cells reverting to immature embryonic cells. The book ends with a summary of the molecular and cellular causes of cancer and an outlook for novel therapies. Throughout the text, the emphasis is on structure and mechanism and is well illustrated with 200 figures. The Biochemistry of Cell Signalling will be an invaluable companion to all graduate students studying cell signalling.


ßçûê: en

Ðóáðèêà: Áèîëîãèÿ/

Ñòàòóñ ïðåäìåòíîãî óêàçàòåëÿ: Ãîòîâ óêàçàòåëü ñ íîìåðàìè ñòðàíèö

ed2k: ed2k stats

Ãîä èçäàíèÿ: 2001

Êîëè÷åñòâî ñòðàíèö: 357

Äîáàâëåíà â êàòàëîã: 22.12.2005

Îïåðàöèè: Ïîëîæèòü íà ïîëêó | Ñêîïèðîâàòü ññûëêó äëÿ ôîðóìà | Ñêîïèðîâàòü ID
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Ïðåäìåòíûé óêàçàòåëü
$\beta$-catenin, and cancer      287—292
$\beta_2$ adrenergic receptor      77-78
$\beta_2$ adrenergic receptor, desensitisation      81—82
$\beta_2$ adrenergic receptor, signalling pathway      78
5-HT (serotonin) receptor      77
Abl tyrosine kinases      38
Activins      102 103t
ADAM proteins      5—6
Adaptor proteins and linkers, ankyrin repeats      37 38
Adaptor proteins and linkers, G proteins      43—45
Adaptor proteins and linkers, notch repeats      37
Adaptor proteins and linkers, PH domain plate      4 (2p) 35—36
Adaptor proteins and linkers, phosphotyrosine phosphatases      37—38 41—43
Adaptor proteins and linkers, PTB domain      35—36 37
Adaptor proteins and linkers, Ras      46—49 50
Adaptor proteins and linkers, SH2 domain plate      2 (lp) 33—34
Adaptor proteins and linkers, SH3 domain plate      3 (2p) 34—35
Adaptor proteins and linkers, sterile $\alpha$-motif (SAM)      37 38
Adaptor proteins and linkers, tyrosine kinases plate      5 (3p) 37—40
Adenomatous polyposis coli (APC) gene/protein      286—292
Adenylate cyclase, adenylyl cyclase—$G_s-\alpha$ complex plate      10 (6p)
Aldosterone, structure      195
Allosteric activation, of proteins      132—133
Ankyrin repeats      37 38
Antibodies, structure      255—256
Antigen presentation plate      28 (15p) 251—252 253 254
Antigen receptors plate      29 (16p) 255—257
Apoptosis and cancer      243—245
Apoptosis and immune system function      245 246
Apoptosis and nervous system development      245
Apoptosis and self-tolerance      263
Apoptosis, prevention plate      27 (15p) 241—243
Apoptosis, promotors      234—241
Arrestin and G-protein coupled receptor signalling      83
Arrestin and receptor desensitisation      81—82 83
B cells, activation      250—251
B cells, antigen receptors      255
B cells, signalling pathways      258—259
B cells, survival and death      261—263
Basic helix-loop-helix (bHLH), motif      162—163
Basic helix-loop-helix (bHLH), structure plate      17 (10p)
Bax and apoptosis      241
Bax and cancer      243—245
Bcl-2 and apoptosis      241—243
Bcl-2 and cancer      243—245
Bcl-2-$X_L$, structure plate      27 (15p)
Bone morphogenetic proteins (BMPs)      102 103 103t 104
Brain-derived neurotrophic factor (BDNF)      14 15t
Breast cancer, and oestrogen receptor      197 199
Calcineurin, structure plate      13 (7p) 126
cAMP and G-protein coupled, receptors      78 79
cAMP and G-protein coupled,i n olfaction      95—96
cAMP response-element-binding protein (CREB)      174
Cancer, and adenomatous polyposis coli (APC) gene      286—287
Cancer, and adenomatous polyposis coli (APC) protein      287—292
Cancer, and apoptosis      243—245
Cancer, and DNA viruses      299—300
Cancer, and loss of developmental control      284—285
Cancer, and retroviral infection      270—271 299
Cancer, inherited cancer genes      294—295
Cancer, oncogenes      269—276
Cancer, proto-oncogene mutations      295—299
Cancer, tumour-suppressor genes      276—282
Caspases plate      26 (14p) 237—238 239
Caveolae, and glucose transport      141 143
CBL protein, and cancer      273
CD (cluster of differentiation) receptors, and immune response      256—257
CD95 receptor, and apoptosis      235
Cdc42 GTPase      64—65
Cdc42 GTPase, and cytoskeleton assembly      65—70
Cdc42 GTPase, and Wiskott — Aldrich syndrome protein (WASP)      73
Cdc42 GTPase, control of phospholipases      70—72
Cell adhesion, and cancer      287—289
Cell adhesion, role of integrins      68t 69—70
Cell cycle, checkpoint control      228—230 295—299
Cell cycle, chromosome duplication      225 226
Cell cycle, cyclin-dependent kinases      see “Cyclin-dependent kinases (Cdks)”
Cell cycle, cyclins      214 215
Cell cycle, cytokinesis      226—228
Cell cycle, DNA replication      224—225
Cell cycle, evolution of      230
Cell cycle, phases      213
Cell death, programmed      see “Apoptosis”
Cell lineage differentiation, cytokine functions      117—119
cGMP, in visual response      90—92
Chaperones, and steroid hormone receptors      197 198
Chaperonins, and steroid hormone receptors      197 198
Chemotaxis      70—72
Chemotaxis, G protein control of      89—90
Chromosome duplication      225 226
Colony-stimulating factors (CSFs)      117 118t
Colony-stimulating factors (CSFs), processing      7
Cortisol, structure      195
Covalent activation, of proteins      132—133
CREB (cAMP response-element-binding protein)      174
Crk adaptor protein      31—32
Csk kinase      40
Cyclin-dependent kinases (Cdks)      214
Cyclin-dependent kinases (Cdks), and cell-cycle transitions      216—224
Cyclin-dependent kinases (Cdks), and DNA replication      224—225
Cyclin-dependent kinases (Cdks), and evolution of the cell cycle      230
Cyclin-dependent kinases (Cdks), cyclin-dependent-kinase inhibitor (CKI) plate      25 (14p)
Cyclins      214 215 see
Cytochrome c, and apoptosis      238 240
Cytokines, and cell lineage differentiation      117—119
Cytokines, and embryonic development      116—117
Cytokines, and T cell differentiation      252—254 255t
Cytokines, antiviral effects      118 119
Cytokines, JAK/STAT signalling pathway      111—116
Cytokines, receptors      110—111 114
Cytokinesis      226—228
Cytoskeleton assembly, role of GTPases      65—70
Cytosolic kinases      123
DAF-2, receptor      17—18
DAF-2, signalling pathway      148—149
Death receptors      235—236 237
Development, and steroid hormone receptors      193—195
Development, embryonic, cytokine functions      116—117
Development, embryonic, STATs      116—117
Development, loss of control of, and cancer      284—285
Development, of nervous system, and apoptosis      245
Diabetes      137—138
DNA tumour viruses      299—300
DNA, damage      240—241
DNA, histone modification      166—167
DNA, methylation      167—168 297
DNA, nucleosomes plate      22 (12p) 165—166
DNA, replication      224—225
DNA, synthesis      62—63
DNA-binding proteins, structural motifs      plate 15 (9p) plate plate plate plate plate plate 161-4
Ecdysone receptor      192—193
Ecdysteroids      192
EGF      see “Epidermal growth factor (EGF)”
Embryonic development, cytokine functions      116—117
Eph-like receptors      9t 18 37 38
Ephrins      9t
Epidermal growth factor (EGF), EGF receptor and cancer      272
Epidermal growth factor (EGF), signal transduction mechanisms      9t 10—11
Erythropoietin (EPO) receptor, ligand-dependent dimerization      25—27
Estrogen receptor      see “Oestrogen receptor”
Fibroblast growth factors (FGFs), signal transduction mechanisms      9t 12—14
Focal adhesion kinase (FAK), integrin-FAK signalling system      68—70
Fos/Jun transcription factors      172—174
G proteins, $G_1-\alpha 1$ subunit plate      8 (5p)
G proteins, $\alpha\beta\gamma$-holocomplex structure plate      7 (4p)
G proteins, $\beta\gamme$-subunit functions      79—80
G proteins, and cancer      273
G proteins, G-$\alpha$ subunit structure plate      6 (4p)
G proteins, GDP/GTP cycle      43—45
G proteins, heterotrimeric G proteins      88—90
G proteins, in visual response plate      12 (7p)
G proteins, monomeric G proteins      89—90
G proteins, Ras/GAP complex structure plate      9 (5p)
G proteins, Ras/MAP kinase pathway      57—64
G proteins, Rho/Rac/Cdc42 GTPases      65—73
G-protein-coupled receptors, and olfaction      92—96
G-protein-coupled receptors, and Ras/MAP kinase pathway      83—85
G-protein-coupled receptors, and taste transduction      96—97
G-protein-coupled receptors, and visual response      90—92
G-protein-coupled receptors, control of hormonal signalling      79—81
G-protein-coupled receptors, receptor desensitisation      81—2 83
G-protein-coupled receptors, rhodopsin activation      85—88
G-protein-coupled receptors, second messenger signalling      plate 10 (6p) plate 78 79
G-protein-coupled receptors, structure      76—78
GATA transcription factors      175
GDNF (glial-cell-line-derived neurotrophic factor)      14—17
GDP/GTP cycle, $G_1 - \alpha 1$ subunit plate      8 (5p)
GDP/GTP cycle, $\alpha\beta\gamma$-holocomplex structure plate      7 (4p)
GDP/GTP cycle, and cell signalling      43—45
GDP/GTP cycle, G-$\alpha$ subunit structure plate      6 (4p)
GDP/GTP cycle, Ras/GAP complex plate      9 (5p)
Gene transcription      see “Transcription”
Genomic imprinting      167—168
Glial-cell-line-derived neurotrophic factor (GDNF)      14—17
Glucose, homeostasis, insulin actions      140—142
Glucose, protein glycation      138 139
Glutamic-acid-rich proteins (GARPs), in visual response      91
Glycation, of proteins      138 139
Glycogen phosphorylase, regulation by phosphorylation dephosphorylation      130—132
Glycogen phosphorylase, structure plate      14 (8p)
Grb2 (growth-factor-receptor-binding protein), SH2 and SH3 domains      32 34—35
Growth factor receptors and cancer      272
Growth factors, and cancer      271—272
Growth factors, processing      5—8
Growth hormone (GH) receptor, binding domain structure plate      l (lp)
Growth hormone (GH) receptor, ligand-dependent dimerization      24—25
GTPase-activating proteins (GAPs), and control of Ras activity      46—48
GTPases      43—45
GTPases, and cytoskeleton assembly      65—70
GTPases, control of phospholipases      69 70—72
GTPases, Ras superfamily      64—65
GTPases, signalling pathways      72—73
Guanine nucleotide release proteins (GNRPs), and control of Ras activity      48—49 50
Gusducin, and taste transduction      96—97
Haematopoietic cells, differentiation, cytokine functions      117—119
Heat-shock protein (Hsp) system, and steroid hormone receptors      197 198
Hepatocyte growth factor (HGF)      9t 18
HGF-like factor      9t
Histones      165-6
Histones, modification      166—167
Histones, nucleosome core particle structure plate      22 (12p)
Homeodomain proteins      162 163
Homeodomain proteins, MAT$\alpha2$/MCM1/DNA complex structure plate      15 (9p)
Homeotic genes      162 193—5
Immune response      250—251 259—260
Immune response, antigen presentation plate      28 (15p) 251—252
Immune response, antigen receptors plate      29 (16p) 255—257
Immune response, lymphocyte survival and death      261—263
Immune response, lymphoid organs      250 251
Immune response, signalling pathways in T cells and B cells      258—259
Immune response, T cell differentiation      252—254 255t
Immune response, T cell selection      252
Immune surveillance, and apoptosis      246
Immunoglobulins, structure      255—256
Imprinting, of genes      167—168
Insulin receptor, homologues      17—18
Insulin receptor, insulin receptor substrates (IRS)      143—146
Insulin receptor, signal transduction mechanisms      9t 17
Insulin receptor, structure      11
Insulin, and glucose homeostasis      140—142
Insulin, as growth factor      137 142—150
Insulin, functions      137—40
Insulin, history      137
Insulin, processing      8
Insulin, signal transduction mechanisms      9t
Insulin, signalling pathways      142—150
Insulin-like factor, signal transduction mechanisms      9t
Integrin-FAK signalling system      68—70
Integrins      65—70
Interferons      118 119
Interleukin-1$\beta$-converting enzyme (ICE) plate      26 (14p) 237
Interleukins, and T cell differentiation      252—254 255t
JAK/STAT signalling pathway, and cytokines      111—116
JNKs (Jun N-terminal kinases)      60
Jun/Fos transcription factors      172—174
Juvenile hormone (JH)      195
Keratinocyte growth factors (KGFs)      9t 12
KIT receptor      9t 14
KL ligand      9t 14
Leptin, cross-talk with insulin signalling pathways      148—150
Leucine zipper motif      162 163
Ligands, growth factor processing      5—8
Linker proteins      see “Adaptor proteins”
Lymphocytes      see “B cells” “T
Macrophage colony-stimulating factor-1 (MCSF-1)      9t
Macrophage colony-stimulating factor-1 (MCSF-1), signal transduction mechanisms      11
MAD proteins      176
Major histocompatibility complex (MHC), and antigen presentation      251—252 253 254
Major histocompatibility complex (MHC), and antigen receptor, structure plate      29 (16p)
MAP kinase pathway      see “Ras/MAP kinase pathway”
MAP kinases      60—62
MAP kinases, role in growth and proliferation      62—63
MAPKKs (MEKs)      60
Mast cell growth factor      9t 14
MAT$\alpha$2/MCM1/DNA complex, structure plate      15 (9p)
MCSF-1 (macrophage colony-stimulating factor-1)      9t
Metalloproteinases, and growth factor processing      5—6
Methylation, of genes      167—168
Methylation, of genes, and cancer      297
MHC      see “Major histocompatibility complex (MHC)”
Mitochondria, and apoptosis      238 240
Mitogen-activated protein kinases      see “MAP kinases”
Morphogenesis, TGF-$\beta$ signalling pathway      108—109
Multi-enzyme organelles, phosphorylation cascades      129—130
Nerve growth factor (NGF), and apoptosis      245
Nerve growth factor (NGF), p75NGFR      15—16 245
Nerve growth factor (NGF), signal transduction mechanisms      14—17
Nervous system development, and apoptosis      245
Neuregulin      9t
Neurofibromin      1
Neurofibromin, and control of Ras activity      47—48
Neurotrophins      14—17
Neurotrophins and apoptosis      245
NF-$\kappa$B transcription factor      164 175
NF-$\kappa$B transcription factor, NF-$\kappa$B/p52/DNA complex plate      23 (13p)
NF-$\kappa$B transcription factor, structure plate      18 (10p)
NF-AT transcription factor      174—175
NF-AT transcription factor, NF-AT/Jun/Fos/DNA complex plate      23 (13p)
NF-xB transcription factor      175
NGF      see “Nerve growth factor(NGF)”
Notch repeats      37
Nuclear receptors, for non-steroids      see “Retinoic acid receptors (RARs)” “Retinoid “Thyroid
Nuclear receptors, for steroid hormones      see “Steroid hormone receptors”
Nuclear transport, and transcriptional control      181—182 183
Nucleosomes      165—166
Nucleosomes, core particle structure plate      22 (12p)
Oestradiol, structure      199
Oestrogen receptor, and breast cancer      197 199
Olfaction, neuronal connections      92—93
Olfaction, odorant receptors      93—95
Olfaction, odorants      93
Olfaction, signal transduction in olfactory neurons      95—96
Oncogenes, and proto-oncogene functions      269—271
Oncogenes, and signalling pathways      271—273
Oncogenes, transformation from protooncogenes      273—276
Oxidative stress, stress activated transcription factors      179—180
p53, and cancer      243—245 279 280—282
p53, structure plate      30 (16p)
p75NGFR, and apoptosis      245
p75NGFR, signal transduction mechanisms      15—16
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