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Helmreich E.J.M. Ч Biochemistry of Cell Signalling
Helmreich E.J.M. Ч Biochemistry of Cell Signalling

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Ќазвание: Biochemistry of Cell Signalling

јвтор: Helmreich E.J.M.


The Biochemistry of Cell Signalling deals in depth with the principles of cell signalling, concentrating on structure and mechanism. It will serve as a reliable map through the maze of cell signalling pathways and help the reader understand how malfunctions in these pathways can lead to disease. The book is divided into four parts. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor activation), regulators, and the molecules that link receptor and regulator. The design of signalling cascades is explained by describing central signalling pathways: the Ras-regulated MAPK and PI-3 pathways; the Rho/Rac/Cdc 42 pathway controlling chemotaxis and regulating the cytoskeleton; the G protein coupled receptor cascades in response to sensory and hormonal signals; signalling by TGF-ss in morphogenesis; cytokine signalling that controls haemopoiesis. There is also a discussion of the insulin response. As phosphorylation - dephosphorylation is involved in nearly all cellular regulatory processes, Part 1 concludes with a synopsis of its role in signalling. Part 2 describes the implementation of the signalling cascades focusing on the effect on gene transcription. After a brief description of the transcriptional machinery the regulation of transcription by cytokines and growth factors in the control of cell growth and the mechanisms and sites of control are discussed in detail. The regulators discussed include Jun/Fos, NF-AT, SREBPs, and STATs. The next two chapters cover gene regulation by nuclear receptors, including both the steroid hormone receptors and non-steroid nuclear receptors e.g. the retinoic acid receptors RAR and RXR. Part 3 studies the global cellular regulatory programs for the control of cell growth and proliferation. The first chapter concerns the regulation of the cell cycle and the role of the cyclin-dependent kinases, telomerase, Ran, and cell cycle checkpoints. The next topic is the signalling pathways in apoptosis: the TNF-receptor family death receptors, caspases, and the intracellular apoptosis signals and the role of apoptosis in the lifecycle of cells. Part 3 ends with a discussion of the signal pathways involved in the immune response, focusing on the involvement of cell-cell interactions. Part 4 considers loss of regulatory control and its consequences with respect to the molecular basis of cancer. It first describes the cellular regulatory proteins that have oncogenic potential, how they can become oncogenic and cause the transformation of normal cells to cancerous cells. Next is an analysis of the loss of developmental controls, the APC protein, ss-catenin, and the Wnt pathway, that lead to mature terminally differentiated cells reverting to immature embryonic cells. The book ends with a summary of the molecular and cellular causes of cancer and an outlook for novel therapies. Throughout the text, the emphasis is on structure and mechanism and is well illustrated with 200 figures. The Biochemistry of Cell Signalling will be an invaluable companion to all graduate students studying cell signalling.

язык: en

–убрика: Ѕиологи€/

—татус предметного указател€: √отов указатель с номерами страниц

ed2k: ed2k stats

√од издани€: 2001

 оличество страниц: 357

ƒобавлена в каталог: 22.12.2005

ќперации: ѕоложить на полку | —копировать ссылку дл€ форума | —копировать ID
ѕредметный указатель
$\beta$-catenin, and cancer      287Ч292
$\beta_2$ adrenergic receptor      77-78
$\beta_2$ adrenergic receptor, desensitisation      81Ч82
$\beta_2$ adrenergic receptor, signalling pathway      78
5-HT (serotonin) receptor      77
Abl tyrosine kinases      38
Activins      102 103t
ADAM proteins      5Ч6
Adaptor proteins and linkers, ankyrin repeats      37 38
Adaptor proteins and linkers, G proteins      43Ч45
Adaptor proteins and linkers, notch repeats      37
Adaptor proteins and linkers, PH domain plate      4 (2p) 35Ч36
Adaptor proteins and linkers, phosphotyrosine phosphatases      37Ч38 41Ч43
Adaptor proteins and linkers, PTB domain      35Ч36 37
Adaptor proteins and linkers, Ras      46Ч49 50
Adaptor proteins and linkers, SH2 domain plate      2 (lp) 33Ч34
Adaptor proteins and linkers, SH3 domain plate      3 (2p) 34Ч35
Adaptor proteins and linkers, sterile $\alpha$-motif (SAM)      37 38
Adaptor proteins and linkers, tyrosine kinases plate      5 (3p) 37Ч40
Adenomatous polyposis coli (APC) gene/protein      286Ч292
Adenylate cyclase, adenylyl cyclaseЧ$G_s-\alpha$ complex plate      10 (6p)
Aldosterone, structure      195
Allosteric activation, of proteins      132Ч133
Ankyrin repeats      37 38
Antibodies, structure      255Ч256
Antigen presentation plate      28 (15p) 251Ч252 253 254
Antigen receptors plate      29 (16p) 255Ч257
Apoptosis and cancer      243Ч245
Apoptosis and immune system function      245 246
Apoptosis and nervous system development      245
Apoptosis and self-tolerance      263
Apoptosis, prevention plate      27 (15p) 241Ч243
Apoptosis, promotors      234Ч241
Arrestin and G-protein coupled receptor signalling      83
Arrestin and receptor desensitisation      81Ч82 83
B cells, activation      250Ч251
B cells, antigen receptors      255
B cells, signalling pathways      258Ч259
B cells, survival and death      261Ч263
Basic helix-loop-helix (bHLH), motif      162Ч163
Basic helix-loop-helix (bHLH), structure plate      17 (10p)
Bax and apoptosis      241
Bax and cancer      243Ч245
Bcl-2 and apoptosis      241Ч243
Bcl-2 and cancer      243Ч245
Bcl-2-$X_L$, structure plate      27 (15p)
Bone morphogenetic proteins (BMPs)      102 103 103t 104
Brain-derived neurotrophic factor (BDNF)      14 15t
Breast cancer, and oestrogen receptor      197 199
Calcineurin, structure plate      13 (7p) 126
cAMP and G-protein coupled, receptors      78 79
cAMP and G-protein coupled,i n olfaction      95Ч96
cAMP response-element-binding protein (CREB)      174
Cancer, and adenomatous polyposis coli (APC) gene      286Ч287
Cancer, and adenomatous polyposis coli (APC) protein      287Ч292
Cancer, and apoptosis      243Ч245
Cancer, and DNA viruses      299Ч300
Cancer, and loss of developmental control      284Ч285
Cancer, and retroviral infection      270Ч271 299
Cancer, inherited cancer genes      294Ч295
Cancer, oncogenes      269Ч276
Cancer, proto-oncogene mutations      295Ч299
Cancer, tumour-suppressor genes      276Ч282
Caspases plate      26 (14p) 237Ч238 239
Caveolae, and glucose transport      141 143
CBL protein, and cancer      273
CD (cluster of differentiation) receptors, and immune response      256Ч257
CD95 receptor, and apoptosis      235
Cdc42 GTPase      64Ч65
Cdc42 GTPase, and cytoskeleton assembly      65Ч70
Cdc42 GTPase, and Wiskott Ч Aldrich syndrome protein (WASP)      73
Cdc42 GTPase, control of phospholipases      70Ч72
Cell adhesion, and cancer      287Ч289
Cell adhesion, role of integrins      68t 69Ч70
Cell cycle, checkpoint control      228Ч230 295Ч299
Cell cycle, chromosome duplication      225 226
Cell cycle, cyclin-dependent kinases      see УCyclin-dependent kinases (Cdks)Ф
Cell cycle, cyclins      214 215
Cell cycle, cytokinesis      226Ч228
Cell cycle, DNA replication      224Ч225
Cell cycle, evolution of      230
Cell cycle, phases      213
Cell death, programmed      see УApoptosisФ
Cell lineage differentiation, cytokine functions      117Ч119
cGMP, in visual response      90Ч92
Chaperones, and steroid hormone receptors      197 198
Chaperonins, and steroid hormone receptors      197 198
Chemotaxis      70Ч72
Chemotaxis, G protein control of      89Ч90
Chromosome duplication      225 226
Colony-stimulating factors (CSFs)      117 118t
Colony-stimulating factors (CSFs), processing      7
Cortisol, structure      195
Covalent activation, of proteins      132Ч133
CREB (cAMP response-element-binding protein)      174
Crk adaptor protein      31Ч32
Csk kinase      40
Cyclin-dependent kinases (Cdks)      214
Cyclin-dependent kinases (Cdks), and cell-cycle transitions      216Ч224
Cyclin-dependent kinases (Cdks), and DNA replication      224Ч225
Cyclin-dependent kinases (Cdks), and evolution of the cell cycle      230
Cyclin-dependent kinases (Cdks), cyclin-dependent-kinase inhibitor (CKI) plate      25 (14p)
Cyclins      214 215 see
Cytochrome c, and apoptosis      238 240
Cytokines, and cell lineage differentiation      117Ч119
Cytokines, and embryonic development      116Ч117
Cytokines, and T cell differentiation      252Ч254 255t
Cytokines, antiviral effects      118 119
Cytokines, JAK/STAT signalling pathway      111Ч116
Cytokines, receptors      110Ч111 114
Cytokinesis      226Ч228
Cytoskeleton assembly, role of GTPases      65Ч70
Cytosolic kinases      123
DAF-2, receptor      17Ч18
DAF-2, signalling pathway      148Ч149
Death receptors      235Ч236 237
Development, and steroid hormone receptors      193Ч195
Development, embryonic, cytokine functions      116Ч117
Development, embryonic, STATs      116Ч117
Development, loss of control of, and cancer      284Ч285
Development, of nervous system, and apoptosis      245
Diabetes      137Ч138
DNA tumour viruses      299Ч300
DNA, damage      240Ч241
DNA, histone modification      166Ч167
DNA, methylation      167Ч168 297
DNA, nucleosomes plate      22 (12p) 165Ч166
DNA, replication      224Ч225
DNA, synthesis      62Ч63
DNA-binding proteins, structural motifs      plate 15 (9p) plate plate plate plate plate plate 161-4
Ecdysone receptor      192Ч193
Ecdysteroids      192
EGF      see УEpidermal growth factor (EGF)Ф
Embryonic development, cytokine functions      116Ч117
Eph-like receptors      9t 18 37 38
Ephrins      9t
Epidermal growth factor (EGF), EGF receptor and cancer      272
Epidermal growth factor (EGF), signal transduction mechanisms      9t 10Ч11
Erythropoietin (EPO) receptor, ligand-dependent dimerization      25Ч27
Estrogen receptor      see УOestrogen receptorФ
Fibroblast growth factors (FGFs), signal transduction mechanisms      9t 12Ч14
Focal adhesion kinase (FAK), integrin-FAK signalling system      68Ч70
Fos/Jun transcription factors      172Ч174
G proteins, $G_1-\alpha 1$ subunit plate      8 (5p)
G proteins, $\alpha\beta\gamma$-holocomplex structure plate      7 (4p)
G proteins, $\beta\gamme$-subunit functions      79Ч80
G proteins, and cancer      273
G proteins, G-$\alpha$ subunit structure plate      6 (4p)
G proteins, GDP/GTP cycle      43Ч45
G proteins, heterotrimeric G proteins      88Ч90
G proteins, in visual response plate      12 (7p)
G proteins, monomeric G proteins      89Ч90
G proteins, Ras/GAP complex structure plate      9 (5p)
G proteins, Ras/MAP kinase pathway      57Ч64
G proteins, Rho/Rac/Cdc42 GTPases      65Ч73
G-protein-coupled receptors, and olfaction      92Ч96
G-protein-coupled receptors, and Ras/MAP kinase pathway      83Ч85
G-protein-coupled receptors, and taste transduction      96Ч97
G-protein-coupled receptors, and visual response      90Ч92
G-protein-coupled receptors, control of hormonal signalling      79Ч81
G-protein-coupled receptors, receptor desensitisation      81Ч2 83
G-protein-coupled receptors, rhodopsin activation      85Ч88
G-protein-coupled receptors, second messenger signalling      plate 10 (6p) plate 78 79
G-protein-coupled receptors, structure      76Ч78
GATA transcription factors      175
GDNF (glial-cell-line-derived neurotrophic factor)      14Ч17
GDP/GTP cycle, $G_1 - \alpha 1$ subunit plate      8 (5p)
GDP/GTP cycle, $\alpha\beta\gamma$-holocomplex structure plate      7 (4p)
GDP/GTP cycle, and cell signalling      43Ч45
GDP/GTP cycle, G-$\alpha$ subunit structure plate      6 (4p)
GDP/GTP cycle, Ras/GAP complex plate      9 (5p)
Gene transcription      see УTranscriptionФ
Genomic imprinting      167Ч168
Glial-cell-line-derived neurotrophic factor (GDNF)      14Ч17
Glucose, homeostasis, insulin actions      140Ч142
Glucose, protein glycation      138 139
Glutamic-acid-rich proteins (GARPs), in visual response      91
Glycation, of proteins      138 139
Glycogen phosphorylase, regulation by phosphorylation dephosphorylation      130Ч132
Glycogen phosphorylase, structure plate      14 (8p)
Grb2 (growth-factor-receptor-binding protein), SH2 and SH3 domains      32 34Ч35
Growth factor receptors and cancer      272
Growth factors, and cancer      271Ч272
Growth factors, processing      5Ч8
Growth hormone (GH) receptor, binding domain structure plate      l (lp)
Growth hormone (GH) receptor, ligand-dependent dimerization      24Ч25
GTPase-activating proteins (GAPs), and control of Ras activity      46Ч48
GTPases      43Ч45
GTPases, and cytoskeleton assembly      65Ч70
GTPases, control of phospholipases      69 70Ч72
GTPases, Ras superfamily      64Ч65
GTPases, signalling pathways      72Ч73
Guanine nucleotide release proteins (GNRPs), and control of Ras activity      48Ч49 50
Gusducin, and taste transduction      96Ч97
Haematopoietic cells, differentiation, cytokine functions      117Ч119
Heat-shock protein (Hsp) system, and steroid hormone receptors      197 198
Hepatocyte growth factor (HGF)      9t 18
HGF-like factor      9t
Histones      165-6
Histones, modification      166Ч167
Histones, nucleosome core particle structure plate      22 (12p)
Homeodomain proteins      162 163
Homeodomain proteins, MAT$\alpha2$/MCM1/DNA complex structure plate      15 (9p)
Homeotic genes      162 193Ч5
Immune response      250Ч251 259Ч260
Immune response, antigen presentation plate      28 (15p) 251Ч252
Immune response, antigen receptors plate      29 (16p) 255Ч257
Immune response, lymphocyte survival and death      261Ч263
Immune response, lymphoid organs      250 251
Immune response, signalling pathways in T cells and B cells      258Ч259
Immune response, T cell differentiation      252Ч254 255t
Immune response, T cell selection      252
Immune surveillance, and apoptosis      246
Immunoglobulins, structure      255Ч256
Imprinting, of genes      167Ч168
Insulin receptor, homologues      17Ч18
Insulin receptor, insulin receptor substrates (IRS)      143Ч146
Insulin receptor, signal transduction mechanisms      9t 17
Insulin receptor, structure      11
Insulin, and glucose homeostasis      140Ч142
Insulin, as growth factor      137 142Ч150
Insulin, functions      137Ч40
Insulin, history      137
Insulin, processing      8
Insulin, signal transduction mechanisms      9t
Insulin, signalling pathways      142Ч150
Insulin-like factor, signal transduction mechanisms      9t
Integrin-FAK signalling system      68Ч70
Integrins      65Ч70
Interferons      118 119
Interleukin-1$\beta$-converting enzyme (ICE) plate      26 (14p) 237
Interleukins, and T cell differentiation      252Ч254 255t
JAK/STAT signalling pathway, and cytokines      111Ч116
JNKs (Jun N-terminal kinases)      60
Jun/Fos transcription factors      172Ч174
Juvenile hormone (JH)      195
Keratinocyte growth factors (KGFs)      9t 12
KIT receptor      9t 14
KL ligand      9t 14
Leptin, cross-talk with insulin signalling pathways      148Ч150
Leucine zipper motif      162 163
Ligands, growth factor processing      5Ч8
Linker proteins      see УAdaptor proteinsФ
Lymphocytes      see УB cellsФ УT
Macrophage colony-stimulating factor-1 (MCSF-1)      9t
Macrophage colony-stimulating factor-1 (MCSF-1), signal transduction mechanisms      11
MAD proteins      176
Major histocompatibility complex (MHC), and antigen presentation      251Ч252 253 254
Major histocompatibility complex (MHC), and antigen receptor, structure plate      29 (16p)
MAP kinase pathway      see УRas/MAP kinase pathwayФ
MAP kinases      60Ч62
MAP kinases, role in growth and proliferation      62Ч63
MAPKKs (MEKs)      60
Mast cell growth factor      9t 14
MAT$\alpha$2/MCM1/DNA complex, structure plate      15 (9p)
MCSF-1 (macrophage colony-stimulating factor-1)      9t
Metalloproteinases, and growth factor processing      5Ч6
Methylation, of genes      167Ч168
Methylation, of genes, and cancer      297
MHC      see УMajor histocompatibility complex (MHC)Ф
Mitochondria, and apoptosis      238 240
Mitogen-activated protein kinases      see УMAP kinasesФ
Morphogenesis, TGF-$\beta$ signalling pathway      108Ч109
Multi-enzyme organelles, phosphorylation cascades      129Ч130
Nerve growth factor (NGF), and apoptosis      245
Nerve growth factor (NGF), p75NGFR      15Ч16 245
Nerve growth factor (NGF), signal transduction mechanisms      14Ч17
Nervous system development, and apoptosis      245
Neuregulin      9t
Neurofibromin      1
Neurofibromin, and control of Ras activity      47Ч48
Neurotrophins      14Ч17
Neurotrophins and apoptosis      245
NF-$\kappa$B transcription factor      164 175
NF-$\kappa$B transcription factor, NF-$\kappa$B/p52/DNA complex plate      23 (13p)
NF-$\kappa$B transcription factor, structure plate      18 (10p)
NF-AT transcription factor      174Ч175
NF-AT transcription factor, NF-AT/Jun/Fos/DNA complex plate      23 (13p)
NF-xB transcription factor      175
NGF      see УNerve growth factor(NGF)Ф
Notch repeats      37
Nuclear receptors, for non-steroids      see УRetinoic acid receptors (RARs)Ф УRetinoid УThyroid
Nuclear receptors, for steroid hormones      see УSteroid hormone receptorsФ
Nuclear transport, and transcriptional control      181Ч182 183
Nucleosomes      165Ч166
Nucleosomes, core particle structure plate      22 (12p)
Oestradiol, structure      199
Oestrogen receptor, and breast cancer      197 199
Olfaction, neuronal connections      92Ч93
Olfaction, odorant receptors      93Ч95
Olfaction, odorants      93
Olfaction, signal transduction in olfactory neurons      95Ч96
Oncogenes, and proto-oncogene functions      269Ч271
Oncogenes, and signalling pathways      271Ч273
Oncogenes, transformation from protooncogenes      273Ч276
Oxidative stress, stress activated transcription factors      179Ч180
p53, and cancer      243Ч245 279 280Ч282
p53, structure plate      30 (16p)
p75NGFR, and apoptosis      245
p75NGFR, signal transduction mechanisms      15Ч16
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