This book constitutes the refereed proceedings of the 6th IFIP WG 6.1 International Conference on Distributed Applications and Interoperable Systems, DAIS 2006, held in Bologna, Italy in June 2006. The DAIS conference was held as a joint event in federation with the 8th IFIP WG 6.1 International Conference on Formal Methods for Open Object-Based Distributed Systems (FMOODS 2006) and the 8th International Conference on Coordination Models and Languages (Coordination 2006).

The 21 regular and 5 work-in-progress papers presented were carefully reviewed and selected from 99 submissions. The papers focus on architectures, models, technologies and platforms for interoperable, scalable and adaptable systems and cover subjects as methodological aspects, tools and language of building adaptable distributed and interoperable services, fault tolerance and dependability, peer-to-peer systems, mobility issues, web services applications and performance issues and composition, semantic web and semantic integration, and context- and location-aware applications.